Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis
نویسندگان
چکیده
منابع مشابه
Clonal architecture of secondary acute myeloid leukemia.
BACKGROUND The myelodysplastic syndromes are a group of hematologic disorders that often evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie progression from the myelodysplastic syndromes to secondary AML are not well understood. METHODS We performed whole-genome sequencing of seven paired samples of skin and bone marrow in seven subjects with secondary AML t...
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Clonal diversity in cancer has been proposed as a mechanism underlying patientto-patient variability in therapeutic response, as well as the variability in the likelihood of relapse and the time to relapse of acute myeloid leukemia (AML) as well as other cancers. As a neoplasm develops it often continues to mutate, diversifying into differing clonal populations. Darwinian evolutionary pressures...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2016
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2016.345